1. Basic Information

Chemical name: 2-chloro-1 - (4-fluorophenyl) -2-phenylethyl ketone

Structural formula：

Molecular formula：C₁₄H₁₀ClFO

Molecular weight：248.68

CAS：62148-67-8

Physical properties: Pale yellow to brown oily substance

2.Process Introduction

2-chloro-1 - (4-fluorophenyl) -2-phenylethyl ketone is derived from phenylacetic acid as the starting material, which is acylated with sulfuryl chloride to obtain phenylacetyl chloride. Then, under the catalysis of aluminum trichloride, it undergoes a Friedel-crafts reaction with fluorobenzene to synthesize the intermediate: Finally, 1- (4-fluorophenyl) -2-acetophenone undergoes a substitution reaction with sulfonyl chloride to yield 2-chloro-1 - (4-fluorophenyl) -2-acetophenone.